Investigators have found DNA at the home of Nancy Guthrie, the missing mother of US news anchor Savannah Guthrie, which does not belong to her or those in close contact to her, local officials said.

The Pima County Sheriff's Department reported that they are working to identify the DNA's source but declined to disclose its exact location within the property.

Additionally, several gloves were found, with one discovered approximately two miles from Nancy Guthrie's home.

The 84-year-old disappeared from her Tucson, Arizona, home nearly two weeks ago, and authorities suspect she may have been taken against her will.

According to the sheriff's department, reports claiming a glove was found inside her home or on the property were inaccurate. All collected evidence is undergoing laboratory analysis.

"We are pursuing every lead," said a sheriff's spokesperson.

Recently, the FBI released a physical description of a suspect suspected of involvement, identified as a male between 5 feet 9 inches and 5 feet 10 inches tall, with an average build.

Footage from a doorbell camera outside Guthrie's home has allowed investigators to establish identifying details about the suspect, who was seen wearing a 25-litre Ozark Trail Hiker Pack backpack.

After the doorbell footage was published, investigators received over 13,000 tips, including about 4,000 in the first 24 hours.

The FBI has also increased the reward for information regarding Guthrie's disappearance from $50,000 to $100,000.

While the suspect description is considered a key focus of the investigation, officials are leaving no stone unturned.

Authorities have issued a broader appeal for video footage from neighbors in the area, reminding citizens that Nancy Guthrie requires daily medication and has limited mobility.

In response to the ongoing crisis, Savannah Guthrie and her siblings have taken to social media, making heartfelt pleas directed at their mother's abductor. They remain hopeful for her safe return and are willing to offer a reward.