LOUISVILLE, Ky. (AP) — A tragic accident occurred on November 4, 2025, when a UPS cargo plane tragically crashed shortly after takeoff from Louisville Muhammad Ali International Airport, leading to the loss of at least seven lives.

The McDonnell Douglas MD-11 aircraft, which had taken off towards Honolulu, experienced a fire in its left wing around 5:15 PM. Initial reports indicate that both crew members and individuals on the ground were among the deceased, with four individuals not aboard the plane losing their lives in the incident.

Kentucky Governor Andy Beshear confirmed that more than a dozen individuals suffered significant injuries as a result of the catastrophe. Eyewitness reports describe a scene filled with flames and thick smoke, with video footage capturing the dramatic moments leading up to the explosion.

The Aftermath and Response

Emergency responders reported that the fire caused extensive destruction, spanning nearly a city block. The airport was closed immediately following the incident, halting all operations for the foreseeable future as investigations began.

UPS, which operates its largest package handling facility in Louisville, issued a statement recognizing the crash and confirming that the National Transportation Safety Board would oversee the investigation. The company suspended package sorting operations as a precaution.

Expert Analysis

Aviation attorney Pablo Rojas commented on the incident, suggesting that the plane struggled for altitude as fire engulfed its left side. Rojas highlighted that due to the large fuel load, once the flames ignited, an explosion was highly predictable. The incident raises concerns about flight safety procedures, particularly regarding fire detection and emergency management on board.

As investigations continue, residents and authorities alike are left to grapple with the shocking impacts of this tragic event.