In his statement, Murthy underscored that alcohol is the third leading preventable cause of cancer, behind tobacco and obesity, and highlighted the risks associated with various alcoholic drinks, such as beer, wine, and spirits. The cancers mentioned include breast cancer in women, as well as those of the throat, liver, esophagus, mouth, larynx, and colon. He recommends increased awareness and education regarding this risk and encourages healthcare providers to screen for alcohol use and make necessary referrals.

While the US currently mandates warning labels regarding the dangers of drinking during pregnancy, and the impairing effects of alcohol on driving, Murthy's proposals would require Congressional action to revise existing policies, which have remained unchanged since 1988. The likelihood of these changes is uncertain, particularly with the potential opposition from the incoming Trump administration.

Globally, awareness around alcohol-related health risks has been growing, with 47 countries implementing alcohol warning labels to varying extents. Notably, Ireland will be the first nation to require labels connecting any level of alcohol consumption to cancer, effective from 2026. In South Korea, cancer-specific warnings are also mandated.

With bodies like the World Health Organization revealing that no amount of alcohol is considered completely safe, various countries have begun tightening their alcohol consumption guidelines. Canada has shifted its recommendation to a maximum of two drinks per week for both men and women. Conversely, the US recommends a maximum of two drinks per day for men and one for women while the UK proposes a weekly limit of around 14 units of alcohol.

The announcement by the Surgeon General has had immediate market repercussions, with shares of leading alcoholic beverage companies dropping by up to 4%, reflecting investor concerns over potential changes in public will and regulatory environments regarding alcohol consumption.