Controversy Erupts as Donor's Cancer-Linked Sperm Produces Nearly 200 Children

Wed Dec 10 2025 20:30:06 GMT+0200 (Eastern European Standard Time)

A major investigation reveals that a sperm donor carrying a cancer-causing genetic mutation has unknowingly fathered 197 children across Europe, raising ethical and health concerns over donor screening practices.

A recent investigation has brought to light that a sperm donor, unknowingly carrying a genetic mutation associated with a high risk of developing cancer, has fathered at least 197 children across Europe. The mutation affects the TP53 gene important in cancer prevention, which has alarmed health experts as some children are already diagnosed with cancer, and certain fatalities have occurred. The sperm was predominantly distributed through clinics in Denmark, with individual countries having unique regulations on sperm donor usage. The case has reignited discourse on the necessity of stringent screening practices and potential limits on donor utilization to avoid similar risks in the future.

Controversy Erupts as Donor's Cancer-Linked Sperm Produces Nearly 200 Children

A sperm donor who unknowingly harbored a genetic mutation that significantly increases the risk of cancer has become the father of at least 197 children across Europe, prompting serious ethical and health concerns.

Some of the children linked to this donor have tragically succumbed to cancer, highlighting an urgent call for better regulation in the sperm donation industry. Although the donor was healthy and passed initial screening checks, the TP53 gene in some of his sperm carried mutations that raise the lifetime cancer risk significantly.

The sperm in question, sold to various fertility clinics primarily in Denmark, was not distributed in the UK, but a small number of British families were affected due to treatment in Denmark. Families involved have been informed, as the report highlights an alarming breach of safety regulations where too many children were born from this donor's sperm.

This investigation, which included collaboration from 14 public service broadcasters under the European Broadcasting Union's Investigative Journalism Network, found that the sperm was collected from an anonymous man in 2005 and used over 17 years.

Experts like Prof Clare Turnbull of the Institute of Cancer Research express concern over the implications of such diagnoses, which not only impact the health of children but also carry a profound emotional burden for families. Annual monitoring, including MRI scans and ultrasounds, is often necessary to detect potential cancers early.

Doctors have observed direct links between this donor's sperm and cancer development in children, with significant numbers affected. This investigation revealed approximately 197 children, but the final numbers remain uncertain as data from all clinics is not yet collected.

While the European Sperm Bank takes responsibility for and has halted the use of this donor’s sperm, the broader debate continues over the lack of cohesive international standards for sperm donation.

Countries maintain varying limits on how many families can utilize the same donor, and the absence of strict regulations at an international level raises concerns about potentially hazardous genetic transmission in the future.