Kyiv has long been calling for its Western partners to provide it with weapons that could hit major Russian cities far from the front line, arguing that they would help Ukraine seriously weaken Russia's military industry and bring the war to an end.
If the cost of continuing the war for Moscow is too high, it will be forced to start peace talks, deputy defence minister Ivan Havryliuk told the BBC.
Kremlin spokesman Dmitry Peskov played down Vance's suggestion, saying there was no panacea that can change the situation on the front for the Kyiv regime.
Tomahawk missiles have a range of 2,500 km (1,550 miles), putting Moscow within reach for Ukraine. While Vance's remarks were ambivalent, the US special envoy to Ukraine, Keith Kellogg, indicated Trump had authorized strikes deep into Russian territory under certain conditions.
This comes amidst a backdrop of escalating violence; a recent 12-hour attack left multiple casualties in Kyiv. Ukraine is seeking additional support, including tarnishing Russian military capacity through advanced weaponry.
As the situation unfolds, the response from Moscow and implications of increased US involvement remain uncertain, leaving both sides on a precarious path amid ongoing conflict.